TEMPORARY PROTECTION OF UKRAINIAN CITIZENS IN THE LIGHT OF THE WAR CRISIS IN THE EXAMPLE OF THE CZECH REPUBLIC AND THE REPUBLIC OF POLAND - SELECTED ISSUES

Temporary protection of Ukrainian citizens in the light of the war crisis in the example of the Czech Republic and the Republic of Poland - selected issues

This article deals with the current refugee crisis related to an ongoing armed conflict in Ukraine, its solutions, and its consequences from the perspective of the Czech Republic and Poland.As such, presented article focuses on Ukrainian citizens reception and black knight darts integration rights development in the Czech Republic and Poland, with

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cAMP/PKA regulates osteogenesis, adipogenesis and ratio of RANKL/OPG mRNA expression in mesenchymal stem cells by suppressing leptin.

BACKGROUND: Mesenchymal stem cells (MSCs) are a pluripotent cell type that can differentiate into adipocytes, osteoblasts and other cells.The reciprocal relationship between adipogenesis and osteogenesis was previously demonstrated; however, the mechanisms remain largely unknown.METHODS AND FINDINGS: We report that activation of PKA by 3-isobutyl-1

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Exploration of the immunogenetic landscape of hyperprogressive disease after combined immunotherapy in cancer patients

Summary: The immune-genetic changes that occur in cancer patients experiencing hyperprogressive disease (HPD) during combined immunotherapy are unclear.In this study, HPD patients with pre- and post-HPD samples and non-HPD patients with solid tumors were molecularly characterized by genetic and 310.32.42.50.01.001 tumor immune microenvironment (TiM

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Analysis of Cryptococcal Extracellular Vesicles: Experimental Approaches for Studying Their Diversity Among Multiple Isolates, Kinetics of Production, Methods of Separation, and Detection in Cultures of Titan Cells

ABSTRACT Extracellular vesicles (EVs) produced by members of the Cryptococcus genus are associated with fundamental processes of fungal physiology and virulence.However, several questions about the properties of cryptococcal EVs remain unanswered, mostly because of technical limitations.We recently described a fast and efficient protocol of high-yi

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